郎曌博课题组

一、近5年内发表的代表性论著:

(1)Zhaobo Lang; Yihai Wang; Kai Tang; Dengguo Tang; Tatsiana Datsenka; Jingfei Cheng; Yijing Zhang; Avtar K. Handa; Jian-Kang Zhu ; Critical roles of DNA demethylation in the activation of r ipening-induced genes and inhibition of ripening-repressed genes in tomato fruit, Proceedings of the National Academy of Sciences, USA(PNAS), 2017, 114(22): 4511-4519

(2)Qingfeng Niu; Siqun Wu; Hongtao Xie; Qi Wu; Ping Liu; Yaping Xu; Zhaobo Lnag ; Efficient A·T to G·C Base Conversions in Dicots Using Adenine Base Editors Expressed under the Tomato EF1 α Promoter, Plant Biotechnology Journal, 2021

(3)Huan Huang; Ruie Liu; Qingfeng Niu; Kai Tang; Bo Zhang; Heng Zhang; Kunsong Chen; Jian-Ka ng Zhu; Zhaobo Lang ; Global increase in DNA methylation during orange fruit development and ripe ning, Proceedings of the National Academy of Sciences, 2019, 116(4): 201815441-1436

(4)Jingfei Cheng; Qingfeng Niu; Bo Zhang; Kunsong Chen; Ruihua Yang; Jian-Kang Zhu; Yijing Zhang; Zhaobo Lang ; Downregulation of RdDM during strawberry fruit ripening, Genome Biology, 2018, 19(1): 212

(5)Dengguo Tang; Philippe Gallusci; Zhaobo Lang ; Fruit development and epigenetic modificat ions, New Phytologist, 2020, 228: 839-844


二、已发表的其余论著:

(1)Zhaobo Lang; Mingguang Lei; Xingang Wang; Kai Tang; Daisuke Miki; Huiming Zhang; Satendra

K. Mangrauthia; Wenshan Liu; Wenfeng Nie; Guojie Ma; Jun Yan; Cheng-Guo Duan; Chuan-Chih Hsu; Chu nlei Wang; W. Andy Tao; Zhizhong Gong; Jian-Kang Zhu ; The methyl-CpG-binding protein MBD7 facili tates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing, Molecular Cell, 2015, 57(6): 971-83

(2)Zhaobo Lang; Zhizhong Gong ; Small RNA biogenesis: Novel roles of an RNase III enzyme, Na ture Plants, 2016, 2

(3)Qingzhu Zhang; Dong Wang; Zhaobo Lang; Li He; Lan Yang; Liang Zeng; Yanqiang Li; Cheng Zh ao; Huan Huang; Heng Zhang; Huiming Zhang; Jian-Kang Zhu ; Methylation interactions in Arabidopsi s hybrids require RNA-directed DNA methylation and are influenced by genetic variation, Proceedin gs of the National Academy of Sciences, U S A(PNAS), 2016, 113(29): 4248-56

(4)Jiemeng Xu; Kai Hua; Zhaobo Lang ; Genome editing for horticultural crop improvement, Hor ticulture Research, 2019, 6(1): 113

(5)Pei Huang; Huan Huang; Xueqiang Lin; Pan Liu; Lun Zhao; Wen-Feng Nie; Jian-Kang Zhu; Zhao bo Lang ; MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset o f target regions of RNA-directed DNA methylation, the Plant Journal, 2021, 108: 347-357

(6)Ruie Liu; Zhaobo Lang ; The mechanism and function of active DNA demethylation in plants,

Journal of Integrative Plant Biology, 2020, 62: 148-159

(7)Qingfeng Niu; Siqun Wu; Yansha Li; Xiaoxuan Yang; Ping Liu; Yaping Xu; Zhaobo Lang ; Expa nding the scope of CRISPR/Cas9‐mediated genome editing in plants using an xCas9 and Cas9‐NG hyb rid, Journal of Integrative Plant Biology, 2020, 62(4): 402

(8)Qingfeng Niu; Zhe Song; Kai Tang; Lixian Chen; Lisi Wang; Ting Ban; Zhongxin Guo; Chanhon g Kim; Heng Zhang; Cheng-Guo Duan; Huiming Zhang; Jian-Kang Zhu; Jiamu Du; Zhaobo Lang ; histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subs et of loci targeted by RNA-directed DNA methylation, Nature Communication, 2021, 12

(9)Zhaobo Lang; Shaojun Xie; Jian-kang Zhu ; The 1001 Arabidopsis DNA Methylomes: An Importa nt Resource for Studying Natural Genetic, Epigenetic, and Phenotypic Variation, Trends in Plant S cience, 2016, 21(11): 906-908

(10)Huiming Zhang; Zhaobo Lang; Jian-Kang Zhu ; Dynamics and function of DNA methylation in plants, Nature Reviews Molecular Cell Biology, 2018, 19: 489-506


三、论著之外的代表性研究成果和学术奖励:

(1)Zhaobo Lang ; Critical roles of DNA demethylation in tomato fruit ripening, XIX Internati onal Botanical Congress (IBC 2017), 深圳, 2017-7-23至2017-7-29(会议报告)

(2)Zhaobo Lang ; Regulation and function of DNA methylation in plants, 2021年全国植物生物学大会, 成都, 2021-12-19至2021-12-22(会议报告)

(3)Zhaobo Lang ; DNA methylation in the tomato fruit ripening, 第五届国际园艺研究大会, 北京, 2018-7-20至2018-7-24(会议报告)

(4)Zhaobo Lang ; Downregulation of RdDM during strawberry fruit ripening, Cold Spring Harbor Asia Conference on Plant Cell and Development Biology, Pohang, 2019-11-3 至2019-11-7(会议报告)

(5)郎曌博(1/1); 2017年 上海市青年拔尖人才

(6)郎曌博(1/1); 2021年 “上海科技青年35人引领计划”入选者