一、近5年内发表的代表性论著：

1. Li He, Yao Yao, Yin You, Xiaofei Wei, Yu Ma, Wei Yuan, Zhaobo Lang, Jian-Kang Zhu. Versatile molecular tools enabling customizable DNA methylation editing in Arabidopsis. Nature Communications. Ahead of print. https://doi.org/10.1038/s41467-025-66933-z

2. Siqun Wu, Yawen Hou, Yu Ma, Pengcheng Wang，Zhaobo Lang. Epigenetic regulation and its applications in plants. Epigenetics Insights. 2025, 18: e010

3. Junhua Kong, Yu Ma, Huan Huang, Virginie Garcia, Qingfeng Niu, Ghislaine Hilbert-Masson, Linda Stammitti, Siqun Wu, Yonglei Yu, Philippe Gallusci, Zhaobo Lang. The grape berry methylome reveals tissue-specific features associated with metabolism in ripening. Horticulture Research. 2025 Sep 17;12(12):uhaf238

4. Lei Zhu, Shiyang Zhang, Qingfeng Niu, Yansha Li, Xiaomu Niu, Pengcheng Wang, Jian-Kang Zhu, Zhaobo Lang.Targeted mutagenesis of SlGAD3 generates very high levels of GABA in commercial tomato cultivars. aBIOTECH. 2025 Sep 22;6(4):693-697

5. Shiyang Zhang, Lei Zhu, Qingfeng Niu, Yansha Li, Xiaomu Niu, Jian-Kang Zhu, Zhaobo Lang. CRISPR/Cas9-mediated editing of uORFs in the tryptophan decarboxylase gene SlTDC1 enhances serotonin biosynthesis in tomato. Plant Biotechnology Journal. 2025 May 31;23(8):3392-3394

6. Qingfeng Niu, Yaping Xu, Huan Huang, Linzhu Li, Dengguo Tang, Siqun Wu, Ping Liu, Ruie Liu, Yu Ma, Bo Zhang, Jian-Kang Zhu, Zhaobo Lang . Two transcription factors play critical roles in mediating epigenetic regulation of fruit ripening in tomato. PNAS. 2025 Apr 15;122(15):e2422798122

7. Yan Xue, Xiaofeng Cao, Xiangsong Chen, Xian Deng, Xing Wang Deng, Yong Ding, Aiwu Don, Cheng-Guo Duan, Xiaofeng Fang, Lei Gong, Zhizhong Gong, Xiaofeng Gu, Chongsheng He, Hang He, Shengbo He, Xin-Jian He, Yan He, Yuehui He, Guifang Jia, Danhua Jiang, Jianjun Jiang, Jinsheng Lai , Zhaobo Lang, Chenlong Li, Qing Li, Xingwang Li, Bao Liu, Bing Liu, Xiao Luo, Yijun Qi, Weiqiang Qian, Guodong Ren, Qingxin Song, Xianwei Song, Zhixi Tian, Jia-Wei Wang, Yuan Wang, Liang Wu, Zhe Wu, Rui Xia, Jun Xiao, Lin Xu, Zheng-Yi Xu, Wenhao Yan, Hongchun Yang, Jixian Zhai, Yijing Zhang, Yusheng Zhao, Xuehua Zhong, Dao-Xiu Zhou, Ming Zhou, Yue Zhou, Bo Zhu, Jian-Kang Zhu, Qikun Liu. Epigenetics in the modern era of crop improvements. Science China Life Sciences. 2025 Jun;68(6):1570-1609

8. Kai Tang, Xiaohong Zhu, Shaojun Xie，Zhaobo Lang，Jian-Kang Zhu. Transgenerational increases in DNA methylation in Arabidopsis plants defective in active DNA demethylation. PNAS. 2024 May 28;121(22):e2320468121

9. Huimin Jia, Yaping Xu, Yuanwen Deng, Yinhuan Xie, Zhongshan Gao, Zhaobo Lang, Qingfeng Niu. Key transcription factors regulate fruit ripening and metabolite accumulation in tomato. Plant Physiology. 2024 Apr 2:kiae195

10. Chao Gu, Mao‑Song Pei, Zhi‑Hua Guo, Lei Wu, Kai‑Jie Qi, Xue‑Ping Wang, Hong Liu, Zhongchi Liu,Zhaobo Lang,Shaoling Zhang. Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism. Genome Biology. 2024 Mar 14;25(1):70.

11. Jinghua Lu, Suhui Lu, Chunli Su, Shuai Deng, Mugui Wang, Huan Tang, Zhunian Wang, Guofu Li, Zhaobo Lang, Jian-Kang Zhu. Tissue culture-free transformation of traditional Chinese medicinal plants with root suckering capability. Horticulture Research. 2023 Dec 29;11(2):uhad290

12. Zhao-Bo Lang, Xiao-Fei Wang. The AP2/ERF transcription factor MdDREB2A regulates nitrogen utilisation and sucrose transport under drought stress. Plant Cell Environment. 2024 Jan 28

13. Peipei Liu, Ruie Liu, Yaping Xu, Caixi Zhang, Qingfeng Niu, Zhaobo Lang. DNA cytosine methylation dynamics and functional roles in horticultural crops. Horticulture Research. 2023 Aug 29;10(10):uhad170

14. Yunduan Li, Yanna Shi, Yichen Li, Jiao Lu, Yunfan Sun, Yuanyuan Zhang, Wenbo Chen, Xiaofang Yang, Donald Grierson, Zhaobo Lang, Guihua Jiang, Kunsong Chen . DNA methylation mediated by RdDM pathway and demethylation affects furanone accumulation through regulation of QUINONE OXIDOREDUCTASE in strawberry. Horticulture Research. 2023 Jul 11;10(8):uhad131

15. Qingfeng Niu, Siqun Wu, Hongtao Xie, Qi Wu, Ping Liu, Yaping Xu, Zhaobo Lang. Efficient A·T to G·C Base Conversions in Dicots Using Adenine Base Editors Expressed under the Tomato EF1α Promoter. Plant Biotechnology Journal. 2023 Jan;21(1):5-7

16. Yuyun Zhang, Zijuan Li, Jinyi Liu, Yu'e Zhang, Luhuan Ye, Yuan Peng, Haoyu Wang, Huishan Diao, Yu Ma, Meiyue Wang, Yilin Xie, Tengfei Tang, Yili Zhuang, Wan. Transposable elements orchestrate subgenome-convergent and -divergent transcription in common wheat. Nature Communications. 2023 May 25;14(1):3014

17. Zhiqiang Duan, Xiaoliang Yang, Xingkun Ji, Ying Chen, Xiaomu Niu, Anping Guo, Jian-Kang Zhu, Feng Li, Zhaobo Lang, Hui Zhao. Cas12a-Based On-Site, Rapid Detection of Genetically Modified Crops. JIPB. 2022 Oct;64(10):1856-1859

18. Ying Gao,Yujing Lin,Min Xu,Hanxiao Bian,Chi Zhang,Jingyu Wang,Hanqing Wang,Yaping Xu,Qingfeng Niu,Jinhua Zuo,Da-Qi Fu,Yu Pan,Kunsong Chen,Harry Klee,Zhaobo. The role and interaction between transcription factor NAC-NOR and DNA demethylase SlDML2 in the biosynthesis of tomato fruit flavor volatiles. New Phytologist. 2022 Sep;235(5):1913-1926

二、已发表的其余论著：

(1)Zhaobo Lang; Mingguang Lei; Xingang Wang; Kai Tang; Daisuke Miki; Huiming Zhang; Satendra

K. Mangrauthia; Wenshan Liu; Wenfeng Nie; Guojie Ma; Jun Yan; Cheng-Guo Duan; Chuan-Chih Hsu; Chu nlei Wang; W. Andy Tao; Zhizhong Gong; Jian-Kang Zhu ; The methyl-CpG-binding protein MBD7 facili tates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing, Molecular Cell, 2015, 57(6): 971-83

(2)Zhaobo Lang; Zhizhong Gong ; Small RNA biogenesis: Novel roles of an RNase III enzyme, Na ture Plants, 2016, 2

(3)Qingzhu Zhang; Dong Wang; Zhaobo Lang; Li He; Lan Yang; Liang Zeng; Yanqiang Li; Cheng Zh ao; Huan Huang; Heng Zhang; Huiming Zhang; Jian-Kang Zhu ; Methylation interactions in Arabidopsi s hybrids require RNA-directed DNA methylation and are influenced by genetic variation, Proceedin gs of the National Academy of Sciences, U S A(PNAS), 2016, 113(29): 4248-56

(4)Jiemeng Xu; Kai Hua; Zhaobo Lang ; Genome editing for horticultural crop improvement, Hor ticulture Research, 2019, 6(1): 113

(5)Pei Huang; Huan Huang; Xueqiang Lin; Pan Liu; Lun Zhao; Wen-Feng Nie; Jian-Kang Zhu; Zhao bo Lang ; MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset o f target regions of RNA-directed DNA methylation, the Plant Journal, 2021, 108: 347-357

(6)Ruie Liu; Zhaobo Lang ; The mechanism and function of active DNA demethylation in plants,

Journal of Integrative Plant Biology, 2020, 62: 148-159

(7)Qingfeng Niu; Siqun Wu; Yansha Li; Xiaoxuan Yang; Ping Liu; Yaping Xu; Zhaobo Lang ; Expa nding the scope of CRISPR/Cas9‐mediated genome editing in plants using an xCas9 and Cas9‐NG hyb rid, Journal of Integrative Plant Biology, 2020, 62(4): 402

(8)Qingfeng Niu; Zhe Song; Kai Tang; Lixian Chen; Lisi Wang; Ting Ban; Zhongxin Guo; Chanhon g Kim; Heng Zhang; Cheng-Guo Duan; Huiming Zhang; Jian-Kang Zhu; Jiamu Du; Zhaobo Lang ; histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subs et of loci targeted by RNA-directed DNA methylation, Nature Communication, 2021, 12

(9)Zhaobo Lang; Shaojun Xie; Jian-kang Zhu ; The 1001 Arabidopsis DNA Methylomes: An Importa nt Resource for Studying Natural Genetic, Epigenetic, and Phenotypic Variation, Trends in Plant S cience, 2016, 21(11): 906-908

(10)Huiming Zhang; Zhaobo Lang; Jian-Kang Zhu ; Dynamics and function of DNA methylation in plants, Nature Reviews Molecular Cell Biology, 2018, 19: 489-506

三、论著之外的代表性研究成果和学术奖励：

(1)Zhaobo Lang ; Critical roles of DNA demethylation in tomato fruit ripening, XIX Internati onal Botanical Congress (IBC 2017), 深圳, 2017-7-23至2017-7-29(会议报告)

(2)Zhaobo Lang ; Regulation and function of DNA methylation in plants, 2021年全国植物生物学大会, 成都, 2021-12-19至2021-12-22(会议报告)

(3)Zhaobo Lang ; DNA methylation in the tomato fruit ripening, 第五届国际园艺研究大会, 北京, 2018-7-20至2018-7-24(会议报告)

(4)Zhaobo Lang ; Downregulation of RdDM during strawberry fruit ripening, Cold Spring Harbor Asia Conference on Plant Cell and Development Biology, Pohang, 2019-11-3 至2019-11-7(会议报告)

(5)郎曌博(1/1); 2017年 上海市青年拔尖人才

(6)郎曌博(1/1); 2021年 “上海科技青年35人引领计划”入选者